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EGFR antibody [GFR/2341]

Anti-EGFR antibody [GFR/2341] used in IHC (Paraffin sections) (IHC-P). GTX17955
Anti-EGFR antibody [GFR/2341] used in Protein Array (Protein Array). GTX17955
Anti-EGFR antibody [GFR/2341] used in IHC (Paraffin sections) (IHC-P). GTX17955

Cat. No. GTX17955

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 GFR/2341

Isotype

 IgG2b

Application

 IHC-P, Protein Array

Reactivity

 Human
Package
100 μg ($529)
See all EGFR products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1-2μg/ml for 30 minutes at RT
Protein Array Assay dependent

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

134 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment of human EGFR protein (around aa 344-492) (exact sequence is proprietary)

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

EGFR , ERBB , ERBB1 , HER1 , NISBD2 , PIG61 , epidermal growth factor receptor , mENA , EGF Receptor

Cellular Localization

Cell membrane,Endoplasmic reticulum membrane,Golgi apparatus membrane,Nucleus membrane,Endosome,Endosome membrane,Nucleus,Secreted

Background

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]

Database

Research Area

DATA IMAGES

Anti-EGFR antibody [GFR/2341] used in IHC (Paraffin sections) (IHC-P). GTX17955

GTX17955 IHC-P Image

IHC-P analysis of human lung sqcc tissue using GTX17955 EGFR antibody [GFR/2341].

Anti-EGFR antibody [GFR/2341] used in Protein Array (Protein Array). GTX17955

GTX17955 Protein Array Image

Analysis of Protein Array containing more than 19,000 full-length human proteins using EGFR Mouse Monoclonal Antibody (GFR/2341). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Anti-EGFR antibody [GFR/2341] used in IHC (Paraffin sections) (IHC-P). GTX17955

GTX17955 IHC-P Image

IHC-P analysis of human placenta tissue using GTX17955 EGFR antibody [GFR/2341].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 529